January 22, 2026 1 min read Glossary

GC-MS

GC-MS

Definition: Gas Chromatography-Mass Spectrometry (GC-MS) is an analytical method that separates chemical mixtures (GC) and identifies the components at a molecular level (MS).

In Context

This is the gold standard for terpene testing. The gas chromatograph vaporizes the sample and separates compounds by volatility, while the mass spectrometer acts as the detector, identifying each compound by its mass-to-charge ratio. It is superior to HPLC for volatile compounds.

Common Misconceptions

GC-MS is not instantaneous or “plug and play.” It requires a skilled technician to interpret the chromatogram and distinguish between isomers (compounds with the same formula but different structures).

Sources

  • [McNair, H. M., & Miller, J. M. (2009). Basic Gas Chromatography. John Wiley & Sons.]